Endocrine Abstracts

Background: Food intake and body weight are in a constant sense of balance, which is tightly regulated. The central control of appetite by the hypothalamus and areas in the brainstem has been established. The peripheral regulation of appetite via gut hormones has also been alluded to – previous studies have shown PYY and ghrelin hormones to be altered in obesity. Glucagon-like peptide-1 is a gut hormone released from L-cells in the distal ileum and colon. It has been impl...

Background: Orlistat is a lipase inhibitor used in the treatment of obesity. Recent published work has shown that orlistat may have a role in affecting the release of appetite regulating gastrointestinal derived peptides. However, the precise effect of orlistat on these hormones remains uncertain. This study aimed to evaluate the short-term effects of orlistat with a high fat meal on levels of plasma Peptide YY (PYY) and on appetite.Methods: Ethical perm...